This time, the rival’s crew as much as assist a cowgirl and her brother “Tom and Jerry Cowboy Up!” save their homestead from a grasping land-grabber, and so they’re going to wish some assist! Jerry’s three precocious nephews are all prepared for motion, and Tom is rounding up a posse of prairie canine. However, can a ragtag band of varmints defeat a deceitful desperado who decided to deceive a damsel in misery? It doesn’t matter what occurs with Tom and Jerry within the saddle, it’ll be a rootin’ tootin’ good time!