Woody, Buzz, and the rest of Andy's toys haven't been played with in years. With Andy about to go to college, the gang find themselves accidentally left at a nefarious day care center. The toys must band together to escape and return home to Andy.

Nemo, an adventurous young clownfish, is unexpectedly taken from his Great Barrier Reef home to a dentist's office aquarium. It's up to his worrisome father Marlin and a friendly but forgetful fish Dory to bring Nemo home -- meeting vegetarian sharks, surfer dude turtles, hypnotic jellyfish, hungry seagulls, and more along the way.