When Will Ferrell's good friend Harper comes out as a trans woman, they take a road trip to bond and reintroduce Harper to the country as her true self.

Tom the cat and Jerry the mouse get kicked out of their home and relocate to a fancy New York hotel, where a scrappy employee named Kayla will lose her job if she can’t evict Jerry before a high-class wedding at the hotel. Her solution? Hiring Tom to get rid of the pesky mouse.